Potentiometric titrations are direct titrations based on principle acid-base titration, redox reaction or precipitation titration. No indicator is used. The voltage across the analyte in electrolyte solution is measured. The specific combination of electrodes, the neutral electrodes and reference electrodes are used to measure the voltage change. The test samples are dissolved in the proper solvent according to monograph, while the automatic electronic burette dispenses the certified titrant into the testing vessel. The millivoltage and dispense volume is recorded. A graph with a sudden change in slope voltage versus volume is observed as the endpoint. The automatic potentiometric titration is used to perform USP/NF monograph assay and purity. The accuracy of the volume titrant dispense is recorded up to three digits in milliliters (i.e. 1.010 mL).
Sample of Report from Automatic Ttitration