Flash Point Determination

The flash point of the liquid, raw material or finished formulation is the lowest temperature where it will evaporate enough fluid to form a combustible concentration of gas. The flash point is an indication of how easily a chemical may burn. The material with higher flash point are less flammable or hazardous. Adamson Laboratories performs flash point determination using the Penky-Martens closed cup method. The determination of flash point by the small scale closed cup method is detailed in ASTM D3828 and D3278, EN ISO 3679 and 3680, and IP 523 and 524. The sample submission must be at least 500 mL.


Below is the safety guide or hazardous grade based on the Flash point temperature:

Hazard Flash Point
Very Low Hazard Flash point > 200°F (93°C)
Moderate Low Hazard Flash point 150°F to 200°F
(66°C to 93°C)
High to Moderate Hazard Flash point 100°F to 150°F
(38°C to 66°C)
Extreme to High Hazard Flash point 0°F to 100°F
(-18°C to 38°C)
Extreme Hazard Flash point < 0°F


Melting Point Determination:

The melting points of drug substances are used in the identification of the substance, as well as to determine substance purity and the presence of contamination. The capillary melting point method is done by heating the capillary tube filled with test substance to 10 degrees below the expected temperature, and increasing the temperature slowly to observe the first sign of liquification. This is the melting point temperature. By slowly increasing the temperature and observing the melting process until almost all the powder turns into liquid, one can determine the melting range of the substance.

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